Consuelo Mancías-Guerra, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Ileana Velasco-Ruiz, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Fabian Cordero-Leija, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Jane C. López-Quesada, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Carlos de la Cruz-de la Cruz, Hematology Service, School of Medicne, “Dr. José Eleuterio González” University Hospital, Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico
Leslie López-Silva, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Sandra Mendoza-Ibarra, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Carlos Cancela-Murrieta, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Óscar González-Llano, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Olga G. Cantú-Rodríguez, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Cesar H. Gutiérrez-Aguirre, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Josué E. Ríos-Solís, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Daniela Arredondo-Campos, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Daniela M. Pérez-Garza, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Sandra A. Sánchez-García, Hematology Service, Universidad Autónoma de Nuevo León, Facultad de Medicina, Hospital Universitario “Dr. José Eleuterio González”, Nuevo León, México
Ricardo M. Cerda-Flores, Centro de Investigación y Desarrollo de Ciencia de la Salud (CIDICS), Universidad Autónoma de Nuevo León, Facultad de Enfermería, Monterrey. México


Objective: Human immune recognition of self and foreign is partially controlled by a set of genes in the human leukocyte antigen complex (HLA). HLA is the most polymorphic region in the human genome, and it is used to assure compatibility between donor and recipient for hematopoietic stem cell transplantation. There are six “classical” HLA genes encoding highly polymorphic loci: HLA-A, B, and C (Class I major histocompatibility complex), and HLA DR, DQ, and DP (Class II). This study aims to quantify the frequency of HLA A, B, C, DRB1, and DQB1 alleles taken in a transplant center in the northeastern part of Mexico. Methods: Descriptive and retrospective data of HLA typing by polymerase chain reactions-SSP for class I and II HLA in our Institution were analyzed. Tests for HLA-A, B, C, DRB1, and DQB1 were performed in 1614 patients. The number of haplotypes found was 726. Results: The most common combinations were A*02, B*35, C*04, DRB1*08, and DQB1*04, which were observed 38 times (5.2%). Conclusion: The most frequent HLA alleles were HLA-A2 and HLA-DQ 03, respectively, with a frequency of 0.2961 and 0.2758.



Keywords: HLA. Mestizo. Northeastern of Mexico. Alleles. Haplotype.