Karen I. Sánchez-Villegas, University Center Against Cancer, “Dr. José Eleuterio González” University Hospital and School of Medicine. Autonomous University of Nuevo León, Monterrey, Nuevo Leon, Mexico Jose F. Muñoz-Lozano, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León., Monterrey, Nuevo Leon, Mexico Larisa M. Renteria-García, Centro Universitario Contra el Cáncer, “Dr. José Eleuterio González” University Hospital and School of Medicine, Universidad Autónoma de Nuevo León., Monterrey, Nuevo Leon, Mexico Oscar Vidal-Gutiérrez, University Center Against Cancer, “Dr. José Eleuterio González” University Hospital and School of Medicine. Autonomous University of Nuevo León, Monterrey, Nuevo Leon, Mexico Carlos E. Salazar-Mejía, University Center Against Cancer, “Dr. José Eleuterio González” University Hospital and School of Medicine. Autonomous University of Nuevo León, Monterrey, Nuevo Leon, Mexico


Managing recurrent cutaneous squamous cell carcinoma (cSCC) usually requires a multidisciplinary approach. A 74-year-old male presented a nodular lesion on the posterior skull. The lesion was resected, and the specimen was classified as a cSCC. Posteriorly, the patient presented recurrent disease. He underwent a craniectomy and a skin flap that was taken from the dorsal skin. Due to adverse pathological characteristics, a radiotherapy regimen consisting of 66 Gy in 33 fractions was administered. After radiotherapy, a complete clinical response was documented. These promising novel treatments for recurrent cSCC still need to be explored in prospective clinical trials.



Keywords: Recurrent cutaneous squamous cell carcinoma. Skin flap. Radiotherapy.